(b) Transition-metal-catalyzed C–H activation followed by addition to imines. (a) α-Branched amine synthesis via addition of organometallic reagents to imines. 15–18 Although the utility of these reactions is well appreciated, several employ the use of precious metal catalysts.Īpproaches to α-branched amines. Here, both transition-metal-catalyzed processes 14 and photoredox catalyzed radical coupling approaches to form C–C bonds have been successfully introduced ( Scheme 1c). 11–13 The α-functionalization of amines toward the formation of α-branched derivatives has also been developed. A more atom economical method employs transition-metal-catalyzed C–H bond activation followed by addition of the resulting organometallic nucleophile to imines ( Scheme 1b). 7–10 Recent years have witnessed remarkable progress in alternative syntheses of α-branched amines. The traditional approach to α-branched amines involves the addition of organometallic reagents, 5,6 such as Grignard reagents and organolithiums, to imines ( Scheme 1a). 4 As such, their synthesis continues to attract attention, with emphasis on rapid access to new chemical space. Amines with α-branching are important functional groups in bioactive compounds, 1 natural products, 2,3 and medications.
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